When lab work gets frustrating, I ask myself: can’t there be an easier way? I’ll hazard a guess that if you’re a chemist like me, you’re inured to the frustration of traditional synthesis. Often, it is the most well-behaved chemical reactions that get you at the end. Yes, I’m talking about that scale-up: that step you promised your adviser would be “facile,” as well as those extra TLCs you could, should, and wish you had done before you started your column. I’m of the opinion that many of the synthetic struggles in the early stages of grad school are essentially self-inflicted. It always cracks me up when I hear someone vigorously complaining about running a notoriously nasty reaction. Honestly, did you really think deciding tackling a McMurry or Skraup wouldn’t cause you just a little bit of sweat? I guess many young grad students, like me, have a burning desire to prove their stripes en route to their secret aspiration: becoming the most interesting
man woman in chemistry.
I’m currently in the midst of working to overcome a synthetic hurdle of my own. Without getting into its provenance or name, I’ll say that I am quite determined to successfully duke it out with this particular reaction. Last week, while I was wrapping up in lab and was in the midst of drawing up the battle plans for the next day’s synthetic attack, I had a rather painful realization. Washing and prepping glassware can be a mind-numbing task and as I stood there essentially doing my dishes, I recalled a recent high impact paper detailing the biosynthesis of quantum dots in earthworms.
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